The Federal Office of Public Health (FOPH) has reported the first Zika virus infection in Switzerland since 2019. It is an imported case. In Switzerland itself, no locally acquired Zika virus infection has been detected so far. Globally, Zika transmissions have been at low levels since 2018. Since the start of mandatory reporting in Switzerland in 2016, the FOPH has registered a total of 75 Zika cases.