Surveillance data from ECDC’s European Respiratory Virus Surveillance Summary (ERVISS) platform and PAHO indicate continued co-circulation of influenza viruses, respiratory syncytial virus (RSV) and SARS-CoV-2 at the start of the 2025–26 Northern Hemisphere winter. In Europe, influenza A predominates with increasing hospitalizations among older adults, while RSV circulation is rising in several countries. SARS-CoV-2 activity persists at lower but stable levels. In the Americas, early-season increases in influenza and RSV activity have been reported following a severe 2025 Southern Hemisphere season.