Between 29 December 2024 and 26 April 2025 (with data for Ecuador as of 2 May 2025), a total of 212 confirmed human cases of yellow fever, including 85 deaths (CFR 40%), have been reported to WHO by five countries in the Region of the America: Bolivia (3 cases, including one death (CFR 33%)); Brazil (110 cases, including 44 deaths (CFR 40%)); Colombia (60 cases, including 24 deaths (CFR 40%)); Ecuador (four fatal cases (CFR 100%)) and Peru (35 cases, 12 deaths (CFR 34%)) (Figure 1).
In 2024, human cases of yellow fever were reported mainly across the Amazon region of Bolivia, Brazil, Colombia, Guyana, and Peru. In 2025, however, cases have been detected mainly in areas outside the Amazon region, including in the state of São Paulo, Brazil and the Tolima department, Colombia. The 212 confirmed yellow fever cases reported so far in 2025 in the Americas represent a threefold increase compared to the 61 confirmed cases reported in 2024.
Vaccination against yellow fever is strongly recommended for all travelers to regions where yellow fever occurs, even if it is not a mandatory requirement for entry into the country. See country-specific recommendations at www.healthytravel.ch.
Note: For Colombia, Peru, and Bolivia, the US CDC has expanded its yellow fever vaccination recommendations to include new regions: see updated CDC map.
For immunocompetent persons, the Swiss Expert Committee for Travel Medicine (ECTM) recommends a single life-time booster 10 years after the primary dose.