The Czech Republic is experiencing a growing surge in hepatitis A cases, with no signs of slowing. In the first four months of 2025 alone, 450 infections and 6 deaths have been reported—compared to 636 cases and 2 deaths during all of 2024.

Health officials warn the true number of infections is likely much higher, given the challenges in tracking the virus spread. The highest number of hepatitis A cases in 2025 have been reported in Prague, the surrounding Central Bohemian region, and the Moravia-Silesian region, which borders Poland and Slovakia. According to officials, the virus is spreading primarily among children, teenagers, young adults, and individuals engaged in "risky behavior." In Prague, nearly one in three patients are homeless, with many also struggling with drug use.